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In peritoneal and bone-marrow-derived macrophages (BMDM), L-serine promotes Interleukin (IL) 1 expression via histone H3 modifications (H3K36me3, H3K9/27 acetylation), and activation of the nucleotide-binding domain and leucine-rich repeat containing proteins 3 (NLRP3) inflammasome 34,83,84